Posts Tagged ‘Cause Of Cancer’

The leading risk factor for lung cancer is smoking. More than 80% of lung cancers are due to cigarette smoking. The longer a person has been smoking and also the more cigarettes a person smokes a day, the greater the risk is for developing lung cancer. Not only are smokers vulnerable to lung cancer, but the people around them are at a greater risk as well due to breathing second-hand smoke. Non-smokers who are married to smokers are at a 30% greater risk than non-smokers who are married to non-smokers. Marijuana cigarettes may also increase the risk of lung cancer since they contain many of the same cancer-causing agents that tobacco cigarettes have and are inhaled more deeply.

Lung cancer most commonly begins in the cells that line your lungs. Smoking causes the majority of lung cancers — both in smokers and in people exposed to secondhand smoke. But lung cancer also occurs in people who never smoked. In these cases, there may be no clear cause of lung cancer. Doctors have identified factors that may increase the risk.

Lung cancer is one of the most common cancers in the world. It is a leading cause of cancer death in men and women in the United States. Cigarette smoking causes most lung cancers. The more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. High levels of pollution, radiation and asbestos exposure may also increase risk.

Causes of Lung Cancer

Smoking: smoking remains the greatest risk factor for lung cancer. Your risk of lung cancer increases with the number of cigarettes you smoke each day and the number of years you have smoked. Quitting at any age can significantly lower your risk of developing lung cancer.

Diet: Scientists are studying many different foods to see how they may change the risk of getting lung cancer. However, any effect diet may have on lung cancer risk is small compared with the risk from smoking. Eating a lot of fat and cholesterol might increase risk of lung cancer. Drinking a lot of alcohol may raise risk as well.

Family History: Studies have found a chromosome that may be resposible for lung cancer. The chromosome can be inherited. If you have had lung cancer before, there is a chance you may develop another type of lung cancer.

Air pollution from vehicles, industry, and power plants can raise the likelihood of developing lung cancer in exposed individuals. Up to 1% of lung cancer deaths are attributable to breathing polluted air, and experts believe that prolonged exposure to highly polluted air can carry a risk similar to that of passive smoking for the development of lung cancer.

Symptoms of Lung Cancer

People often decide to visit the doctor only after they have been bothered by certain complaints over a period of time. Individuals who have lung cancer frequently experience symptoms such as the following:

Metastasis to the bones is most common with small cell type cancers but also occurs with other lung cancer types. Lung cancer that has metastasized to the bone causes bone pain, usually in the backbone (vertebrae), the thighbones, and the ribs.

Shortness of breath usually results from a blockage to the flow of air in part of the lung, collection of fluid around the lung (pleural effusion), or the spread of tumor throughout the lungs.

A cough that does not go away or gets worse over time should be evaluated by a health-care provider.

Chest pain is a symptom in about one-fourth of people with lung cancer. The pain is dull, aching, and persistent and may involve other structures surrounding the lung.

Wheezing or hoarseness may signal blockage or inflammation in the lungs that may go along with cancer.

The breasts sit on the chest muscles that cover the ribs. Each breast is made of 15 to 20 lobes. Lobes contain many smaller lobules. Lobules contain groups of tiny glands that can produce milk. Milk flows from the lobules through thin tubes called ducts to the nipple. The nipple is in the center of a dark area of skin called the areola. Fat fills the spaces between the lobules and ducts.

Breast cancer incidence is much higher in industrialised Western countries, whether in Europe or North America, than in developing countries. North American women have the highest incidence of breast cancer in the world. Among women in the U.S., breast cancer is the most common cancer and the second-most common cause of cancer death (after lung cancer). Women in the U.S. have a 1 in 8 (12.5%) lifetime chance of developing invasive breast cancer and a 1 in 35 (3%) chance of breast cancer causing their death. In 2007, breast cancer was expected to cause 40,910 deaths in the U.S. (7% of cancer deaths; almost 2% of all deaths)

Breast cancer is the most common cause of cancer in women and the second most common cause of cancer death in women in the U.S. While the majority of new breast cancers are diagnosed as a result of an abnormality seen on a mammogram, a lump or change in consistency of the breast tissue can also be a warning sign of the disease. Heightened awareness of breast cancer risk in the past decades has led to an increase in the number of women undergoing mammography for screening, leading to detection of cancers in earlier stages and a resultant improvement in survival rates.

Breast cancer is the number one disease that women in the United States fear the most, and for compelling reasons. It is the leading cause of death among women between 40 and 55 years of age and is the second overall cause of death among women (exceeded only by lung cancer). Unfortunately, it is also on the rise worldwide. According to the American Cancer Society, this year about 175,000 new cases of invasive breast cancer and about 43,300 deaths from breast cancer will occur among women in the USA.

Breast cancer is the most common malignancy affecting women in North America and Europe. Close to 200,000 cases of breast cancer were diagnosed in the United States in 2001. Breast cancer is the second leading cause of cancer death in American women behind lung cancer. The lifetime risk of any particular woman getting breast cancer is about 1 in 8 although the lifetime risk of dying from breast cancer is much lower at 1 in 28. Men are also at risk for development of breast cancer, although this risk is much lower than it is for women.

Breast cancer is more easily treated and often curable if it is found early. Monthly breast self-examinations should begin at age 20. Recommended screening methods include breast self-examination and mammography.

The most serious cancers are metastatic cancers. Metastasis means that the cancer has spread from the place where it started into other tissues distant from the original tumor site. The most common place for breast cancer to metastasize is into the lymph nodes under the arm or above the collarbone on the same side as the cancer. Other common sites of breast cancer metastasis are the brain, the bones, and the liver.

Death rates from breast cancer have been gradually declining and continue to decline. These decreases are likely due both to increased awareness and screening and improved treatment methods.

Lung cancer may be the most tragic cancer because in most cases, it might have been prevented, 87% of lung cancer cases are caused by smoking. Lung cancer has long been the most common cause of cancer death in men and since 1987 it has also become the most common cause of cancer death in women. Lung cancer is the second most commonly occurring form of cancer in most western countries and although the lung cancer incidence is less common in developing countries, the rapid increase in the popularity of smoking will see the number of lung cancer sufferers in those countries quickly catch up with the western world.

Lung cancers can arise in any part of the lung, and 90%-95% of cancers of the lung are thought to arise from the epithelial, or lining cells of the larger and smaller airways (bronchi and bronchioles); for this reason, lung cancers are sometimes called bronchogenic carcinomas or bronchogenic cancers.

The most common type of lung cancers are epidermoid carcinoma, small cell carcinoma, adenocarcinoma and large cell carcinoma.

Most experts agree that lung cancer is attributable to inhalation of carcinogenic pollutants by a susceptible host. Who is most susceptible? Any smoker over the age of 40, especially if they began smoking before the age of 15, have smoked 20 or more for 20 years, or worked with or near asbestos. Two other factors also increase susceptibility: exposure to carcinogenic industrial and air pollutants (asbestos, uranium, arsenic, nickel, iron oxides, chromium, radio active dust, and coal dust.) and familial susceptibility.

SIGNS AND SYMPTOMS

Because early lung cancer usually produces no symptoms, the disease is often in an advanced stage when first diagnosed. Late stage signs are: with epidermoid and small cell carcinoma; smokers cough, hoarseness, wheezing, dyspnea, hemoptysis and chest pain. With adenocarcinoma and large cell carcinoma; fever, weakness, weight loss, anorexia and shoulder pain. In addition, hormone production which regulates various body functions may also be affected.

DIAGNOSIS

Firm diagnosis requires chest x rays, sputum cytology, CT scanning, bronchoscopy the examination of pleural fluid and biopsies. Other tests to detect metastasis include bone scans, bone marrow biopsy and CT scans of the brain and abdomen.

METASTASES

Lung cancer most often spreads to the liver, the adrenal glands, the bones, and the brain. Lung cancer that has metastasized to the bone causes bone pain, usually in the backbone (vertebrae), the thighbones, and the ribs. Lung cancer that spreads to the brain can cause difficulties with vision and weakness on one side of the body.

Lung cancer may grow into certain nerves in the neck, causing a droopy eyelid, small pupil, sunken eye, and reduced perspiration on one side of the face; together these symptoms are called Horner’s syndrome (see Autonomic Nervous System Disorders: Horner’s Syndrome). Lung cancer may grow directly into the esophagus, or it may grow near it and put pressure on it, leading to difficulty in swallowing. Lung cancer may also spread through the bloodstream to the liver, brain, adrenal glands, spinal cord, and bone.

TREATMENT

Treatment for lung cancer depends on the cancer’s specific cell type, how far it has spread, and the patient’s performance status. If investigations confirm lung cancer, CT scan and often positron emission tomography (PET) are used to determine whether the disease is localised and amenable to surgery or whether it has spread to the point where it cannot be cured surgically. Treatment is usually a combination of surgery, chemotherapy and radiation therapy.

Surgery is usually the first option. Chemotherapy can be used as a first line treatment for lung cancer or as additional treatment after surgery. Radiation therapy can be directed at your lung cancer from outside your body (external beam radiation) or it can be put inside needles, seeds or catheters and placed inside your body near the cancer (brachytherapy). Radiation therapy can be used alone or along with other lung cancer treatments. Radiation therapy can also be used to lessen side effects of lung cancer.

Treatment may not be as effective for patients with bone or liver metastases from lung cancer, excessive weight loss, ongoing cigarette use, or pre-existing medical conditions such as heart disease or emphysema. At some point, if you and your oncologist or primary care physician agree that treatment no longer is advisable, hospice care can provide comfort.

Do you find yourself searching for facts about ovarian cancer?

Well here are a couple quick facts for you.

The ovaries belong to the female reproductive system and produce eggs each month during the reproductive years of a woman. You will find that they are located on either side of the woman’s lower abdomen. Ovarian cancer occurs when the cells in the ovary divide and grow in an uncontrollable fashion. The cells may form a tumor on the woman’s ovary or the cells may even break off from the main body and spread to other body parts.

What is the risk of a woman contacting ovarian cancer? It is about 1 in 67.

The risk of getting this type of cancer and dying from it is 1 in 95.

It is the eighth most common cause of cancer in women, excluding skin cancer. Wouldn’t it be well worth your while to be checked out every year whether you notice a problem or not? It would bring peace of mind if nothing else.

There is no way to control how crazily Ovarian cancer cells grow and multiply out of control. These out of control cells form a tumor depriving healthy surrounding cells of much-needed oxygen and nutrients that they require for survival and maximum function. An ovarian tumor can be in just one or in both of the ovaries. Not all tumors are malignant, but if they are that means that they can spread to other organs and tissues of the body which is a process called metastasis.

There are 4 types of ovarian cancers: Epithelial, stromal, germ cell and metastatic tumors.

While testing for ovarian cancer other cell masses can be discovered that are non-cancerous such as abscesses, infections, fibroids, cysts, polycystic ovaries, endometriosis related masses, and also ectopic pregnancies.

Roughly 80% of all ovarian cancers are epithelial in nature and are the most commonly found in menopausal women.

In 10% of ovarian cancer cases, stromal tumors may occur. Surgical removal of the affected ovary is usually all the treatment that is needed unless the cancer has spread.

Tumors that develop from the cells that develop into the ova (the woman’s eggs) develop into germ cell tumors. This type of ovarian cancer usually results in infertility in the woman.

Usually only 5% of ovarian cancers will spread to other body parts but when they do spread most of the time the cancer spreads to the colon, breast, stomach or pancreas.

If a woman’s mother, sister or daughter has ovarian cancer than she has a 5% risk of getting it too. If she has two close relatives (mother, sister, daughter) with ovarian cancer she then has a 50% risk of getting the disease.

There are many risk factors a woman may have for ovarian cancer besides family history including exposure to asbestos, exposure of the genitals to talc, certain virus exposure like that of mumps, being of Ashkenazi Jewish heritage, or of European (white) heritage, having used fertility drugs without a successful pregnancy, age greater than 50 years and women who have never had any children.

Symptoms of ovarian cancer

The first symptoms in thinking that something may be wrong are similar to indigestion and gastrointestinal illness. This makes the diseases hard to diagnose. Due to this fact, many women are not diagnosed until the ovarian cancer has already made headway.

Sign and various symptoms that may suggest ovarian cancer are:

•general abdominal discomfort, pain
•diarrhea, nausea, constipation and frequent urination
•the loss of one’s appetite
•feeling full even only after eating a light meal
•Weight loss or gain for no known reason
•Abnormal bleeding from the vaginal area may occur as a late symptom

Risk factors for ovarian cancer

There are no known causes for ovarian cancer. However, certain studies show that an increased risk of the disease of the following may increase the chance of getting this disease:

•Family history – If your mother, daughter or sister has had the disease, you are at greater risk of getting ovarian cancer.

•Age – Most ovarian cancers will occur in women who are over 50 years of age. The highest risk comes in women who are over 60.

•Non-childbearing – Women who have never experienced the miracle of birth. The fact is, the more children a woman has, the less likely it is that she will develop ovarian cancer.

•Personal history – Those women who have had colon or breast cancer may find themselves at greater risk.

•Obesity – Obese women experience a higher death rate from ovarian cancer.

•Fertility drugs – These may slightly increase a woman’s risk to ovarian cancer.

Treatment:

There are various types of treatment for ovarian cancer consisting of chemotherapy, radiation therapy, and surgery. There is local therapy, which consists of surgery and radiation therapy. The local treatment removes or destroys the cancer. Local therapy can be used to destroy cancer in specific body parts.

Intraperitoneal chemotherapy uses a thin tube to deliver the chemotherapy to the abdomen and pelvis.

The physician uses Systemic chemotherapy to destroy or control cancer throughout the body. This is injected into a vein or delivered orally.

Side effects are common no matter which type of treatment is used because the treatments destroy not just the cancer cells but healthy cells as well. The severity and kind of side effect will depend on the kind and on the length of treatment. Not everyone who receives the same treatment will experience the same side effects.

I hope that these basic facts about ovarian cancer were useful to you.

Pancreatic cancer begins in the tissues of your pancreas, a large organ that lies horizontally behind the lower part of the stomach. Pancreatic cancer occurs most commonly in men between the ages of 35 and 70, it is the fourth most common cause of cancer mortality (behind lung cancer, colorectal cancer and breast cancer). Pancreatic cancer is usually an adenocarcinoma and it usually arises from the pancreatic duct cells which make up the major part of the pancreas.

Cause of pancreatic cancer

Pancreatic cancer is caused by damage to genes, but it is not known exactly why this damage happens. Evidence suggests that it is linked to exposure to carcinogens such as; cigarettes, food high in fat and protein and food additives. Possible predisposing factors are chronic pancreatitis, diabetes mellitus and chronic alcohol abuse.

There is some evidence that people who don’t eat many fresh vegetables and fruits are more at risk from pancreatic cancer. Being overweight may cause a small increase in the risk of pancreatic cancer. Some industrial chemicals called chlorinated hydrocarbon solvents have been linked to pancreatic cancer, although they are unlikely to be a major factor. Other chemicals and exposures that have been linked to an increased risk of pancreatic cancer in some studies include pesticides, radiation, nickel, chromium and iron.

The average age of onset of pancreatic cancer is between 70 to 80 but heavy smokers and heavy drinkers present with pancreatic cancer an average of seven to 10 years earlier than the rest of the population.

Signs and symptoms of pancreatic cancer

The most common are weight loss, abdominal or low back pain, jaundice and diarrhea.

Other more general effects include; fever, skin lesions, depression, anxiety and a premonition of impending death. Ascites ( fluid retention in the abdomen ) can be a sign of pancreatic tumors.

Diagnosis

It is very difficult to diagnose pancreatic cancer as the pancreas is so deep within the body and symptoms vary depending on the exact location of the tumor in the pancreas and which cells or function of the pancreas is affected by the tumour or cancer. Unfortunately the symptoms of pancreatic cancer can also be quite vague and non specific and may be caused by many other more common and less serious conditions.

Pancreatic cancer typically spreads rapidly and is seldom detected in its early stages, which is a major reason why it is a leading cause of cancer death. Pancreatic cancer specialists believe that anyone over 50 who develops diabetes and has unexplained weight loss should be investigated for other pancreatic disease. Courvoisier sign defines the presence of jaundice and a painlessly distended gallbladder as strongly indicative of pancreatic cancer and may be used to distinguish pancreatic cancer from gallstones.

Treatment

Treatment for pancreatic cancer depends on the stage and location of the cancer as well as on your age, overall health and personal preferences. The first goal of pancreatic cancer treatment is to eliminate the cancer, when possible. When that isn’t an option, the focus may be on preventing the pancreatic cancer from growing or causing more harm. Pancreatic cancer is relatively resistant to medical treatment and the only potentially curative treatment is surgery. Radiation therapy for pancreatic cancer can palliate pain but does not affect the patients survival.

Gemcitabine was approved by the US FDA in 1998 after a clinical trial reported improvements in quality of life in patients with advanced pancreatic cancer. Management of pain and other symptoms is an important part of the treatment of advanced pancreatic cancer.

Prognosis

Pancreatic cancer often has a poor prognosis, even when diagnosed early and the median survival period from the time of diagnosis until demise is arguably the worst of any of the cancers. The best predictors of long term survival after surgery are a tumor diameter of less than 3 cm, no nodal involvement, negative resection margins, and diploid tumor DNA content.

Due to difficulties in diagnosis, the aggressive nature of pancreatic cancer and the limited systemic treatments available, the five-year survival rate for patients who have pancreatic adenocarcinoma is only about 5%. For pancreatic cancer that cannot be removed completely with surgery, or cancer that has spread beyond the pancreas, cure is not currently possible and the average survival is usually less than 1 year.

Cancer

The organs and tissues of the body are made up of tiny building blocks called cells. Cancer is a disease of these cells. Cells in different parts of the body may look and work differently but most reproduce themselves in the same way.

Cells are constantly becoming old and dying, and new cells are produced to replace them. Normally, cells divide in an orderly and controlled manner. If for some reason the process gets out of control, the cells carry on dividing, developing into a lump which is called a tumour.

Cancer is a term for diseases in which abnormal cells divide without control and can invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems.

Brain Cancer

A brain tumor is a group or clump of abnormally growing cells that can be found in or on the brain. They’re rare in kids Brain tumors can either start in the brain or spread there from another part of the body – some cancers that start in other parts of the body may have cells that travel to the brain and start growing there.

Lung Cancer

Lung cancer is one of the most common cancers in the world. It is a leading cause of cancer death in men and women in the United States. Cigarette smoking causes most lung cancers. The more cigarettes you smoke per day and the earlier you started smoking, the greater your risk of lung cancer. High levels of pollution, radiation and asbestos exposure may also increase risk. Cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer.

It usually spreads to different parts of the body more slowly than small cell lung cancer. Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma are three types of non-small cell lung cancer. Small cell lung cancer also called oat cell cancer, accounts for about 20% of all lung cancer.

Skin Cancer

Skin cancer is the most common form of cancer in the United States. The two most common types are basal cell cancer and squamous cell cancer. They usually form on the head, face, neck, hands and arms. Another type of skin cancer, melanoma, is more dangerous but less common. Skin cancers are the fastest growing type of cancer in the United States. Skin cancer represents the most commonly diagnosed malignancy, surpassing lung, breast, colorectal and prostate cancer. Cancer that forms in tissues of the skin. There are several types of skin cancer. Skin cancer that forms in melanocytes (skin cells that make pigment) is called melanoma. Skin cancer that forms in basal cells (small, round cells in the base of the outer layer of skin) is called basal cell carcinoma

Ear Cancer

Cancer of the outer ear occurs chiefly in instances where the outer ear has been exposed for many years to direct sunlight. A small and at first painless ulcer, with a dry scab covering it, that slowly enlarges and deepens may be a skin cancer. It is diagnosed by removing a small bit of tissue from the edge and examining it under a microscope.

Head And Neck Cancer

Tobacco is the most preventable cause of these deaths a lump in the neck Cancers that begin in the head or neck usually spread to lymph nodes in the neck before they spread elsewhere. A lump in the neck that lasts more than two weeks should be seen by a physician as soon as possible. Of course, not all lumps are cancer. But a lump (or lumps) in the neck can be the first sign of cancer of the mouth, throat, voice box (larynx), thyroid gland, or of certain lymphomas or blood cancers. Such lumps are generally painless and continue to enlarge steadily.

Lung cancer is the leading cause of cancer deaths in both women and men in the United States and throughout the world. Lung cancer has surpassed breast cancer as the leading cause of cancer deaths in women.

In the United States in 2007, 160,390 people were projected to die from lung cancer, which is more than the number of deaths from colorectal, breast, and prostate cancer combined.

Only about 2% of those diagnosed with lung cancer that has spread to other areas of the body are alive five years after the diagnosis, although the survival rates for lung cancers diagnosed at a very early stage are higher, with approximately 49% surviving for five years or longer.

Some lung tumors are metastatic from cancers elsewhere in the body. The lungs are a common site for metastasis. If this is the case, the cancer is not considered to be lung cancer. For example, if prostate cancer spreads via the bloodstream to the lungs, it is metastatic prostate cancer (a secondary cancer) in the lung and is not called lung cancer.

Cancer occurs when normal cells undergo a transformation that causes them to grow and multiply without the normal controls. The cells form a mass or tumor that differs from the surrounding tissues from which it arises. Tumors are dangerous because they take oxygen, nutrients, and space from healthy cells.

About 90% of lung cancers arise due to tobacco use. Cigarette smoking is the most important cause of lung cancer. Research as far back as the 1950s clearly established this relationship. Cigarette smoke contains more than 4,000 chemicals, many of which have been identified as causing cancer. A person who smokes more than one pack of cigarettes per day has a risk of developing lung cancer 20-25 times greater than someone who has never smoked.

However, Once a person quits smoking, his or her risk for lung cancer gradually decreases. About 15 years after quitting, the risk for lung cancer decreases to the level of someone who never smoked. Cigar and pipe smoking also increases the risk of lung cancer but not as much as smoking cigarettes.

Most lung tumors are malignant. This means that they invade and destroy the healthy tissues around them and can spread throughout the body.

The tumors can also spread to nearby lymph nodes or through the bloodstream to other organs. This process is called metastasis. When lung cancer metastasizes, the tumor in the lung is called the primary tumor, and the tumors in other parts of the body are called secondary tumors or metastatic tumors.

Adenocarcinoma (an NSCLC) is the most common type of lung cancer, making up 30%-40% of all cases. A subtype of adenocarcinoma is called bronchoalveolar cell carcinoma, which creates a pneumonia-like appearance on chest x-rays. Squamous cell carcinoma (an NSCLC) is the second most common type of lung cancer, making up about 30% of all lung cancers. Large cell cancer (another NSCLC) makes up 10% of all cases. SCLC makes up 20% of all cases. And finally, Carcinoid tumors account for only 1% of all cases.

Lung cancers are usually divided into two main groups that account for about 95% of all cases. These division into groups is based on the type of cells that make up the cancer. About 5% of lung cancers are of rare cell types, including carcinoid tumor, lymphoma, and others.

The two main types of lung cancer are characterized by the cell size of the tumor when viewed under the microscope. They are called small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC includes several subtypes of tumors. SCLCs are less common, but they grow more quickly and are more likely to metastasize than NSCLCs. Often, SCLCs have already spread to other parts of the body when the cancer is diagnosed.

Up to one-fourth of all people with lung cancer may have no symptoms when the cancer is diagnosed. These cancers usually are identified incidentally when a chest x-ray is performed for another reason. The majority of people, however, develop symptoms. The symptoms are due to direct effects of the primary tumor, to effects of metastatic tumors in other parts of the body, or to disturbances of hormones, blood, or other systems caused by the cancer.

Symptoms of primary lung cancers include cough, coughing up blood, chest pain, and shortness of breath. Symptoms of metastatic lung tumors depend on the location and size. About 30%-40% of people with lung cancer have some symptoms or signs of metastatic disease.

A cough that does not go away or gets worse over time should be evaluated by a health-care provider. Also, Coughing up blood (hemoptysis) occurs in a significant number of people who have lung cancer. Any amount of coughed-up blood is cause for concern. Chest pain is a symptom in about one-fourth of people with lung cancer. The pain is dull, aching, and persistent and may involve other structures surrounding the lung.

Additionally, shortness of breath usually results from a blockage to the flow of air in part of the lung, collection of fluid around the lung (pleural effusion), or the spread of tumor throughout the lungs. Wheezing or hoarseness may signal blockage or inflammation in the lungs that may go along with cancer. Finally, Repeated respiratory infections, such as bronchitis or pneumonia, can be a sign of lung cancer.

INTRODUCTION

Lung cancer may also be the most tragic cancer because in most cases, it might have been prevented, 87% of lung cancer cases are caused by smoking. Lung cancer has long been the most common cause of cancer death in men and since 1987 it has also become the most common cause of cancer death in women. Lung cancer is the second most commonly occurring form of cancer in most western countries and although the lung cancer incidence is less common in developing countries, the rapid increase in the popularity of smoking will see the number of lung cancer sufferers in those countries quickly catch up with the western world.

Lung cancers can arise in any part of the lung, and 90%-95% of cancers of the lung are thought to arise from the epithelial, or lining cells of the larger and smaller airways (bronchi and bronchioles); for this reason, lung cancers are sometimes called bronchogenic carcinomas or bronchogenic cancers.

The most common type of lung cancers are epidermoid carcinoma, small cell carcinoma, adenocarcinoma and large cell carcinoma.

Most experts agree that lung cancer is attributable to inhalation of carcinogenic pollutants by a susceptible host. Who is most susceptible? Any smoker over the age of 40, especially if they began smoking before the age of 15, have smoked 20 or more for 20 years, or worked with or near asbestos. Two other factors also increase susceptibility: exposure to carcinogenic industrial and air pollutants (asbestos, uranium, arsenic, nickel, iron oxides, chromium, radio active dust, and coal dust.) and familial susceptibility.

SIGNS AND SYMPTOMS

Because early lung cancer usually produces no symptoms, the disease is often in an advanced stage when first diagnosed. Late stage signs are: with epidermoid and small cell carcinoma; smokers cough, hoarseness, wheezing, dyspnea, hemoptysis and chest pain. With adenocarcinoma and large cell carcinoma; fever, weakness, weight loss, anorexia and shoulder pain. In addition, hormone production which regulates various body functions may also be affected.

DIAGNOSIS

Firm diagnosis requires chest x rays, sputum cytology, CT scanning, bronchoscopy the examination of pleural fluid and biopsies. Other tests to detect metastasis include bone scans, bone marrow biopsy and CT scans of the brain and abdomen.

METASTASES

Lung cancer most often spreads to the liver, the adrenal glands, the bones, and the brain. Lung cancer that has metastasized to the bone causes bone pain, usually in the backbone (vertebrae), the thighbones, and the ribs. Lung cancer that spreads to the brain can cause difficulties with vision and weakness on one side of the body.

Lung cancer may grow into certain nerves in the neck, causing a droopy eyelid, small pupil, sunken eye, and reduced perspiration on one side of the face; together these symptoms are called Horner’s syndrome (see Autonomic Nervous System Disorders: Horner’s Syndrome). Lung cancer may grow directly into the esophagus, or it may grow near it and put pressure on it, leading to difficulty in swallowing. Lung cancer may also spread through the bloodstream to the liver, brain, adrenal glands, spinal cord, and bone.

TREATMENT

Treatment for lung cancer depends on the cancer’s specific cell type, how far it has spread, and the patient’s performance status. If investigations confirm lung cancer, CT scan and often positron emission tomography (PET) are used to determine whether the disease is localised and amenable to surgery or whether it has spread to the point where it cannot be cured surgically. Treatment is usually a combination of surgery, chemotherapy and radiation therapy.

Surgery is usually the first option. Chemotherapy can be used as a first line treatment for lung cancer or as additional treatment after surgery. Radiation therapy can be directed at your lung cancer from outside your body (external beam radiation) or it can be put inside needles, seeds or catheters and placed inside your body near the cancer (brachytherapy). Radiation therapy can be used alone or along with other lung cancer treatments. Radiation therapy can also be used to lessen side effects of lung cancer.

Treatment may not be as effective for patients with bone or liver metastases from lung cancer, excessive weight loss, ongoing cigarette use, or pre-existing medical conditions such as heart disease or emphysema. At some point, if you and your oncologist or primary care physician agree that treatment no longer is advisable, hospice care can provide comfort.

Breast cancer is considered as a killer disease and it is known to be the top cause of cancer death among women. According to American cancer society, about 1.3 million new breast cancer cases are diagnosed on an annually basis which includes 465,000 deaths. In order to successfully tackle this devastating disease, we must encourage innovative scientists to study cancer at its most basic level. In other words, breast cancer research work should be conducted at its molecular level. Also, besides the governments, private organizations should provide flexible funding to scientists who will be conducting breast cancer research work. Proper funding of breast cancer research projects; can not only lead to better prevention strategies but it can also help towards earlier diagnostic techniques and new anticancer drugs and treatments.

A world renowned cancer researcher, named Lothar Hirneise has come to an understanding that cancer exist with stress. He is of the opinion that when the mind is under constant stress, the body then produces high levels of stress hormone called Cortisol. The immune system gets suppressed with high levels of Cortisol in the body. Also, a stressed mind will release out Adrenaline to an extent of depletion. People suffering from cancer are found to be having almost no adrenaline in their cells. In fact, cells of cancer patients are often overloaded with insulin and plenty of sugar. Another  leading German cancer researcher by the name of ‘Ryke-Geerd Hamer has gone through twenty thousand cancer patients and found a direct relationship between psycho-emotional conflict and cancer patients. This occurs between 1 to 3 years, prior to cancer diagnosis and cancer forming within the body. Cancer patients, who have experienced a psycho – emotional conflict shock, in the form of loss of a loved one etc, few years prior to their cancer urine, has experienced emotional pain and stress within themselves. Such a state of mind can have an adverse effect on the immune system of the person’s body.

Recently, researchers who are working towards breast cancer research project, have developed and successfully tested a breast cancer vaccine which is likely to treat women with treatment – resistant HER2 – positive breast cancer and thus be able to prevent cancer re – occurrence. Breast cancer researchers look forward to use HER2 DNA vaccines for cancer – free women, in order to prevent initial development of such tumours. At present, therapies such as trastuzumab and lapatimib are used towards treating breast cancer patients. However, it was lately noticed that a huge group of patients develop a resistance towards trastuzumab and lapatimib. HER2 receptors are known to promote a particularly aggressive type of tumour that affects about thirty percent of breast cancer patients.

The new breast cancer vaccine is produced by the body’s own cells. It delivers a cancer fighting gene into cells, which then produce immune system proteins and also tumor – destroying cells. According to the lead researcher Wei – Zen Wei, a professor of immunology and microbiology at the Karmanos Cancer Institute, the vaccine is made by using so – called naked DNA from genes that produces the HER2 receptor. This DNA is put along with an immune stimulant. The process involved in the making of the vaccine, is called as electroporation. In this process, pulses of electricity were used in order to inject the vaccine into the leg muscles in mice. The genes moved towards the cells, which then produced HER2 receptors that led to activation of antibodies and immune cells called Killer T cells. This vaccine is unique and much more research will be further required so that it can one day be applicable towards humans for treating breast cancer.

Overview

When a group of cells display uninhibited growth, which refers to division beyond the normal limits, this phenomenon is commonly referred to as cancer. Other characteristics include an attack and destruction of surrounding tissues, and the spread to other locations in the body via lymph or blood, which is known as metastasis.

These malignant, which refers to a severe and progressively worsening disease, properties of cancers differentiate them from benign tumors, which are self-limited and do not invade or metastasise.

A tumor refers to a swelling or lesion formed by an unusually high growth of cells and occurs with most cancers. However, some, like leukemia, do not produce tumors.

Breast cancer becomes established, initially, in the cells of the breast in men and women. On a worldwide basis, the second most established form of cancer, after lung cancer, is that of breast cancer. It represents 10% of all cancers relating to both sexes. It is the fifth most common cause of cancer death.

The most common type of cancer specifically related to women, globally, is that of breast cancer. It occurs at more than twice the rate of that of colorectal cancer and cervical cancer and about three times that of lung cancer. Further, in the case of women, deaths from breast cancer, worldwide, is approximately 25% more than that from lung cancer.

In a study in 2005, it was found that breast cancer produced 502,000 deaths worldwide. To get this into context, this represents about 7% of all cancer deaths, and nearly 1% of all recorded deaths. Further, there has been a substantial increase, globally, in breast cancer since the 1970s. This statistic, it is suggested, may be associated with modern lifestyles in the western world.

On a global basis, the occurrence of breast cancer differs significantly according to region. It is less widespread in less-developed countries and more so in the further-developed countries. In the twelve designated regions of the world, the annual incidence rates per 100,000 women are as follows: Eastern Asia, 18; Southern Central Asia, 22; sub-Saharan Africa, 22; South-Eastern Asia, 26; North Africa and Western Asia, 28; South and Central America, 42; Eastern Europe, 49; Southern Europe, 56; Northern Europe, 73; Oceania, 74; Western Europe, 78; and in North America, 90.

The United States has the highest incidence rates of breast cancer in women, globally. A study has shown 141 cases among white women and 122 among African American women. Also in the US, breast cancer amongst women is the most prevalent cancer. After lung cancer, it produces the second highest occurrence of deaths from all cancers.

There is a 12.5% chance of women in the US developing invasive breast cancer within their lifetime. Further, there is a 3% chance that the breast cancer that they may contract will actually cause their death. A forecast has suggested that, in 2007, breast cancer would be the cause of 40,910 deaths in the US. This would represent some 7% of cancer deaths, and almost 2% of all deaths.

For the last few years, both the incidence and death rates from breast cancer in the US have been in decline. In 2005, a study conducted in the US by the Society for Women’s Health Research concluded that breast cancer remains the disease that causes the most concern. This is an interesting outcome since heart disease is a much more widespread determinant when considering all deaths among women.

Breast cancer is also prevalent in men. This is due to the fact that the breast is composed of identical tissues in respect of both genders. However, it must be remembered that the manifestation of breast cancer in men is some 100 times less common than that in women.  Conversely, men with breast cancer are considered to have the same statistical survival rates as women.

Breast Cancer – How To Succeed

Peter Radford writes Articles with Websites on a wide range of subjects. Breast Cancer Articles cover Background, Symptoms, Risk, Prevention, Treatment.

His Website contains a total of 41 Breast Cancer Articles, written by others and carefully selected.

View his Website at: breast-cancer-how-to-succeed.com

View his Blog at: breast-cancer-how-to-succeed.blogspot.com