Posts Tagged ‘breast’

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Dr. Jennifer Ashton listed lifestyle changes that can reduce the risk of breast cancer.

The breasts sit on the chest muscles that cover the ribs. Each breast is made of 15 to 20 lobes. Lobes contain many smaller lobules. Lobules contain groups of tiny glands that can produce milk. Milk flows from the lobules through thin tubes called ducts to the nipple. The nipple is in the center of a dark area of skin called the areola. Fat fills the spaces between the lobules and ducts.

Breast cancer incidence is much higher in industrialised Western countries, whether in Europe or North America, than in developing countries. North American women have the highest incidence of breast cancer in the world. Among women in the U.S., breast cancer is the most common cancer and the second-most common cause of cancer death (after lung cancer). Women in the U.S. have a 1 in 8 (12.5%) lifetime chance of developing invasive breast cancer and a 1 in 35 (3%) chance of breast cancer causing their death. In 2007, breast cancer was expected to cause 40,910 deaths in the U.S. (7% of cancer deaths; almost 2% of all deaths)

Breast cancer is the most common cause of cancer in women and the second most common cause of cancer death in women in the U.S. While the majority of new breast cancers are diagnosed as a result of an abnormality seen on a mammogram, a lump or change in consistency of the breast tissue can also be a warning sign of the disease. Heightened awareness of breast cancer risk in the past decades has led to an increase in the number of women undergoing mammography for screening, leading to detection of cancers in earlier stages and a resultant improvement in survival rates.

Breast cancer is the number one disease that women in the United States fear the most, and for compelling reasons. It is the leading cause of death among women between 40 and 55 years of age and is the second overall cause of death among women (exceeded only by lung cancer). Unfortunately, it is also on the rise worldwide. According to the American Cancer Society, this year about 175,000 new cases of invasive breast cancer and about 43,300 deaths from breast cancer will occur among women in the USA.

Breast cancer is the most common malignancy affecting women in North America and Europe. Close to 200,000 cases of breast cancer were diagnosed in the United States in 2001. Breast cancer is the second leading cause of cancer death in American women behind lung cancer. The lifetime risk of any particular woman getting breast cancer is about 1 in 8 although the lifetime risk of dying from breast cancer is much lower at 1 in 28. Men are also at risk for development of breast cancer, although this risk is much lower than it is for women.

Breast cancer is more easily treated and often curable if it is found early. Monthly breast self-examinations should begin at age 20. Recommended screening methods include breast self-examination and mammography.

The most serious cancers are metastatic cancers. Metastasis means that the cancer has spread from the place where it started into other tissues distant from the original tumor site. The most common place for breast cancer to metastasize is into the lymph nodes under the arm or above the collarbone on the same side as the cancer. Other common sites of breast cancer metastasis are the brain, the bones, and the liver.

Death rates from breast cancer have been gradually declining and continue to decline. These decreases are likely due both to increased awareness and screening and improved treatment methods.

Breast cancer is a cancer that starts in the cells of the breast Worldwide, breast cancer is the second most common type of cancer after lung cancer (10.4% of all cancer incidence, both sexes counted) and the fifth most common cause of cancer death. Worldwide, breast cancer is by far the most common cancer amongst women, with an incidence rate more than twice that of colorectal cancer and cervical cancer and about three times that of lung cancer. However breast cancer mortality worldwide is just 25% greater than that of lung cancer in women. In 2005, breast cancer caused 502,000 deaths worldwide (7% of cancer deaths; almost 1% of all deaths).The number of cases worldwide has significantly increased since the 1970s, a phenomenon partly blamed on modern lifestyles in the Western world.

In most cases, it isn’t clear what causes normal breast cells to become cancerous. Doctors do know that only 5 percent to 10 percent of breast cancers are inherited. Families that do have genetic defects in one of two genes, breast cancer gene 1 (BRCA1) or breast cancer gene 2 (BRCA2), have a much greater risk of developing both breast and ovarian cancer. Other inherited mutations — including the ataxia-telangiectasia mutation gene, the cell-cycle checkpoint kinase 2 (CHEK-2) gene and the p53 tumor suppressor gene — also make it more likely that you’ll develop breast cancer. If one of these genes is present in your family, you have a 50 percent chance of having the gene.

Inflammatory breast cancer is a type of breast cancer that involves the skin of the breast. This type of cancer comprises less than 4% of all breast cancers diagnosed each year in the US. The physical symptoms of inflammatory breast cancer include redness of the skin of the breast and a general swelling of the breast. In some cases, a lump may be present.

Types of Breast Cancer

Tumor grade: If the cancer is an invasive type, the pathologist assigns it a grade. The grade is based on how closely cells in the sample tissue resemble normal breast tissue under the microscope. The grading information, along with the cell type, helps your doctor determine treatment options.

Tubular carcinoma: This rare type of breast cancer gets its name from the appearance of the cancer cells under a microscope. Though it’s an invasive breast cancer, the outlook is more favorable than it is for invasive ductal carcinoma or invasive lobular carcinoma.

Metaplastic carcinoma: Met plastic carcinoma represents less than 1 percent of all newly diagnosed breast cancers. This lesion tends to remain localized and contains several different types of cells that are not typically seen in other forms of breast cancer. Prognosis and treatment is the same as for invasive ductal carcinoma.

Lobular Carcinoma In Situ is NOT cancer. But it’s a sign that the woman who has it is 6 to 7 more times likely to develop cancer, over the course of her lifetime, than a woman who doesn’t have LCIS: the same risk you’d be at if your mother and sister both had cancer.

Most lumps turn out to be fibrocystic changes. The term “fibrocystic” refers to fibrosis and cysts. Fibrosis is the formation of fibrous (or scar-like) tissue, and cysts are fluid-filled sacs. Fibrocystic changes can cause breast swelling and pain. This often happens just before a period is about to begin. Your breasts may feel lumpy and, sometimes, you may notice a clear or slightly cloudy nipple discharge.

Breast cancer is a cancer that starts in the cells of the breast Worldwide, breast cancer is the second most common type of cancer after lung cancer (10.4% of all cancer incidence, both sexes counted) and the fifth most common cause of cancer death. Worldwide, breast cancer is by far the most common cancer amongst women, with an incidence rate more than twice that of colorectal cancer and cervical cancer and about three times that of lung cancer. However breast cancer mortality worldwide is just 25% greater than that of lung cancer in women. In 2005, breast cancer caused 502,000 deaths worldwide (7% of cancer deaths; almost 1% of all deaths).The number of cases worldwide has significantly increased since the 1970s, a phenomenon partly blamed on modern lifestyles in the Western world.

In most cases, it isn’t clear what causes normal breast cells to become cancerous. Doctors do know that only 5 percent to 10 percent of breast cancers are inherited. Families that do have genetic defects in one of two genes, breast cancer gene 1 (BRCA1) or breast cancer gene 2 (BRCA2), have a much greater risk of developing both breast and ovarian cancer. Other inherited mutations — including the ataxia-telangiectasia mutation gene, the cell-cycle checkpoint kinase 2 (CHEK-2) gene and the p53 tumor suppressor gene — also make it more likely that you’ll develop breast cancer. If one of these genes is present in your family, you have a 50 percent chance of having the gene.

Inflammatory breast cancer is a type of breast cancer that involves the skin of the breast. This type of cancer comprises less than 4% of all breast cancers diagnosed each year in the US. The physical symptoms of inflammatory breast cancer include redness of the skin of the breast and a general swelling of the breast. In some cases, a lump may be present.

Types of Breast Cancer

Tumor grade: If the cancer is an invasive type, the pathologist assigns it a grade. The grade is based on how closely cells in the sample tissue resemble normal breast tissue under the microscope. The grading information, along with the cell type, helps your doctor determine treatment options.

Tubular carcinoma: This rare type of breast cancer gets its name from the appearance of the cancer cells under a microscope. Though it’s an invasive breast cancer, the outlook is more favorable than it is for invasive ductal carcinoma or invasive lobular carcinoma.

Metaplastic carcinoma: Met plastic carcinoma represents less than 1 percent of all newly diagnosed breast cancers. This lesion tends to remain localized and contains several different types of cells that are not typically seen in other forms of breast cancer. Prognosis and treatment is the same as for invasive ductal carcinoma.

Lobular Carcinoma In Situ is NOT cancer. But it’s a sign that the woman who has it is 6 to 7 more times likely to develop cancer, over the course of her lifetime, than a woman who doesn’t have LCIS: the same risk you’d be at if your mother and sister both had cancer.

Most lumps turn out to be fibrocystic changes. The term “fibrocystic” refers to fibrosis and cysts. Fibrosis is the formation of fibrous (or scar-like) tissue, and cysts are fluid-filled sacs. Fibrocystic changes can cause breast swelling and pain. This often happens just before a period is about to begin. Your breasts may feel lumpy and, sometimes, you may notice a clear or slightly cloudy nipple discharge.

Breast cancer is the most common cancer in women affecting one in eight women during their lives. It may develop at any time but the risk of developing it increases as women get older. It is far more common in post-menopausal women and the risk continues to increase with rising age.

CAUSE

The cause of breast cancer is not known and while it can also occur in men, the much higher occurrence in women implicates estrogen.

Today, breast cancer, like other forms of cancer, is considered to be the final outcome of multiple environmental and hereditary factors.

Breathing secondhand smoke increases breast cancer risk by 70% in younger, primarily pre-menopausal women.

A newly released study indicates a correlation between the drop in breast cancer and the drop in women taking HRT.

SIGNS AND SYMPTOMS

Breast cancer elicits so many fears, including those relating to surgery, death, loss of body image and loss of sexuality, however it is more easily treated and often curable if it is found early, therefore regular self examination and screening is essential. Breast cancer usually shows as a lump or thickening in the breast tissue, although most breast lumps are not cancerous.

Certain predisposing factors are clear.

Women at high risk are those who:

Have a family history of breast cancer.

Have long menstrual cycles, began menses early or menopause late.

Have never been pregnant

Were first pregnant after age 31.

Have had unilateral breast cancer.

Have endometrial or Ovarian cancer.

Were exposed to low level ionizing radiation.

Many other possible factors are still under investigation including, obesity, alcohol and environmental factors.

Those with lower risk include women who:

Were pregnant before age 20.

Have had multiple pregnancies.

Are native American or Asian.

Breast cancer occurs more often in the left breast and in the upper quadrant.

Indications of breast cancer other than a lump may include changes in breast size or shape, skin dimpling, nipple inversion, or spontaneous single-nipple discharge.

TYPES

When breast cancer cells invade the dermal lymphatics, small lymph vessels in the skin of the breast, its presentation can resemble skin inflammation and thus is known as inflammatory breast cancer (IBC). Symptoms of inflammatory breast cancer include pain, swelling, warmth and redness throughout the breast, as well as an orange peel texture to the skin referred to as peau d’orange.

The most common pathologic types of breast cancer are invasive ductal carcinoma, malignant cancer in the breast’s ducts, and invasive lobular carcinoma, malignant cancer in the breast’s lobules.

Occasionally, breast cancer presents as metastatic disease, that is, cancer that has spread beyond the original organ. Bone or joint pains can sometimes be manifestations of metastatic breast cancer, as can jaundice or neurological symptoms.

TREATMENT

Much controversy still exists over treatment of breast cancer, options include; Surgery , chemotherapy, Radiotherapy,Hormonal therapies,Herceptin and complementary treatments.

The mainstay of breast cancer treatment is surgery when the tumor is localized, with possible adjuvant hormonal therapy (with tamoxifen or an aromatase inhibitor), chemotherapy, and/or radiotherapy.

In February 2007, the MammaPrint test became the first breast cancer predictor to win formal approval from the Food and Drug Administration. This is a new gene test to help predict whether women with early-stage breast cancer will relapse in 5 or 10 years, this could help influence how aggressively the initial tumor is treated.

Interstitial laser thermotherapy (ILT) is an innovative method of treating breast cancer in a minimally invasive manner and without the need for surgical removal, and with the absence of any adverse effect on the health and survival of the patient during intermediate follow up.

PREVENTION

Routine (annual) mammography of women older than age 40 or 50 is recommended by numerous organizations as a screening method to diagnose early breast cancer and has demonstrated a protective effect in multiple clinical trials.

Women with one or more first-degree relatives (mother, sister, daughter) with premenopausal breast cancer should begin screening at an earlier age.

PROGNOSIS

There are many prognostic factors associated with breast cancer: staging, tumour size and location, grade, whether disease is systemic (has metastasized, or traveled to other parts of the body), recurrence of the disease, and age of patient.

With advances in screening, diagnosis, and treatment, the death rate for breast cancer has declined by about 20% over the past decade, and research is ongoing to develop even more effective screening and treatment programs.

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